Large Language Models in Scientific Research

The field of scientific research is witnessing a significant shift with the integration of Large Language Models (LLMs) in various domains. Recent studies have demonstrated the potential of LLMs in advancing scientific knowledge and automating complex tasks. The primary direction of this field is towards leveraging LLMs for knowledge discovery, reasoning, and decision-making in scientific domains such as biology, chemistry, and materials science.

Notable advancements include the application of LLMs in predicting enzymatic reactions, enhancing text mining in materials science, and outperforming human experts in challenging biology benchmarks. Additionally, LLMs have shown promise in chemical synthesis and design decision programs, as well as in evaluating the chemical intelligence of large language models.

Some papers are particularly noteworthy, including: LLMs Outperform Experts on Challenging Biology Benchmarks, which demonstrates the superior performance of LLMs over human experts in certain biology tasks. Assessing the Chemical Intelligence of Large Language Models, which evaluates the ability of LLMs to directly perform chemistry tasks without external assistance. BioProBench: Comprehensive Dataset and Benchmark in Biological Protocol Understanding and Reasoning, which introduces a large-scale benchmark for evaluating LLMs on procedural biological texts.

Sources

Leveraging Large Language Models for enzymatic reaction prediction and characterization

Symbol-based entity marker highlighting for enhanced text mining in materials science with generative AI

LLMs Outperform Experts on Challenging Biology Benchmarks

From Knowledge to Reasoning: Evaluating LLMs for Ionic Liquids Research in Chemical and Biological Engineering

LLM-Augmented Chemical Synthesis and Design Decision Programs

Benchmarking Retrieval-Augmented Generation for Chemistry

Assessing the Chemical Intelligence of Large Language Models

BioProBench: Comprehensive Dataset and Benchmark in Biological Protocol Understanding and Reasoning

Benchmarking AI scientists in omics data-driven biological research

Enhancing Thyroid Cytology Diagnosis with RAG-Optimized LLMs and Pa-thology Foundation Models

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